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. Author manuscript; available in PMC: 2011 Sep 10.

Published in final edited form as: FEBS Lett. 2010 Jul 24;584(17):3682–3695. doi: 10.1016/j.febslet.2010.07.029

Fig. 1 — (A) Domain organization of Mre11, Rad50, and Nbs1. (B) Model of intermolecular interactions within the MRN·DNA ternary complex. While there is evidence that multiple MRN complexes can cluster at DNA termini, for simplicity only a single complex is depicted. See text for details. (C) Clustering of MRN complexes at DNA termini, and the subsequent tethering of multiple DNA molecules via the coiled-coil arms of Rad50. The DNA-binding globular heads of the MRN complexes are depicted by spheres.

Fig. 1 — (A) Domain organization of Mre11, Rad50, and Nbs1. (B) Model of intermolecular interactions within the MRN·DNA ternary complex. While there is evidence that multiple MRN complexes can cluster at DNA termini, for simplicity only a single complex is depicted. See text for details. (C) Clustering of MRN complexes at DNA termini, and the subsequent tethering of multiple DNA molecules via the coiled-coil arms of Rad50. The DNA-binding globular heads of the MRN complexes are depicted by spheres.