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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nat Chem. 2010 Aug 8;2(10):847–852. doi: 10.1038/nchem.751

Figure 2. Binding of esters inside a deep-cavity cavitand.

Figure 2

Main spectrum: 1H NMR spectrum in D2O of the 2:1 complex (~1 mM) formed between host 1 and ester 6. High-field guest signals are highlighted. The residual signal from DMSO-d6 arises from the necessity to dissolve the ester in a small volume of DMSO-d6. Upper spectrum: 1H NMR guest binding region for a 2:1:1 ratio of host 1 and esters 5 and 6 (~1 mM host). Integration of selected bound guest signals gives a 0.8:1 ratio of complexes 12.5 and 12.6, respectively and allows calculation of the relative binding affinities of each guest.