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. Author manuscript; available in PMC: 2010 Sep 27.
Published in final edited form as: J Pain. 2000 SUMMER;1(2):151–161. doi: 10.1016/S1526-5900(00)90100-7

Figure 3.

Figure 3

Inhibitory effect of AIDA on DRR activity 4 hours after injection of k/c into the knee-joint cavity. (A) Control DRR activity recorded from the MAN induced by a 2 N von Frey fiber applied on knee (a and d), ankle (b) and foot (c) of an arthritic animal. Spinal cord application of 4 μmol/L AIDA (B) for half an hour, there was little effect on the DRR activity. The infusion of 17 μmo/L AIDA (C), or 30 μmol/L (D) into the spinal cord for half an hour inhibited DRR activity recorded from the MAN (bin width, 1 second). (E) Dose response curve for AIDA was constructed using the spike rate of DRR activity (percentage of control) plotted against the calculated concentrations applied to the spinal cord through the microdialysis fiber (P < .001).