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. 2010 Aug 11;151(10):4811–4819. doi: 10.1210/en.2010-0285

Figure 2.

Figure 2

Intra-PVN administration of dexamethasone causes rapid inhibition of the HPA axis response to restraint. Animals were given bilateral intra-PVN injections of dexamethasone (10 ng per side) or an equimolar amount of dex:BSA (1.25 μg per side), and plasma hormone responses to 25 min of restraint stress were measured. A, Time course of ACTH response to restraint. Dexamethasone and dex:BSA treatment both attenuated the ACTH response to restraint within 15 min of injection. B, Integrated ACTH response to restraint stress (AUC). The magnitude of the integrated ACTH response to restraint was not significantly decreased by either dexamethasone or dex:BSA. C, Time course of corticosterone (CORT) response to restraint. Dexamethasone and dex:BSA both significantly attenuated the corticosterone response to restraint within 60 min of the injection. D, Integrated corticosterone response to restraint. Dexamethasone and dex:BSA both decreased the magnitude of the integrated corticosterone response to restraint. *, P < 0.05 vs. vehicle-treated animals.