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. 2010 Aug 11;151(10):4811–4819. doi: 10.1210/en.2010-0285

Figure 6.

Figure 6

CB1 receptor signaling is necessary for fast feedback. Animals were treated with dexamethasone, the CB1 receptor antagonist AM-251, or both and then subjected to 30 min restraint. Plasma ACTH and corticosterone responses were measured for 60 min after the injection. A, Plasma ACTH response to restraint. Dexamethasone treatment rapidly reduced the magnitude of the ACTH response, whereas AM-251 alone did not affect the stress-induced elevation of ACTH. AM-251 also completely reversed the dexamethasone-induced inhibition of HPA axis activity. B, Total magnitude of ACTH response, expressed as AUC. The magnitude of the integrated ACTH response was lower in dexamethasone-treated animals compared with dexamethasone and AM-251 cotreatment. C, Plasma corticosterone (CORT) response to restraint. Again, dexamethasone decreased the corticosterone response to restraint at 60 min after injection, whereas AM-251 treatment had no effect on the response. AM-251 also completely reversed the dexamethasone-induced inhibition of the corticosterone response. D, AUC of corticosterone secretion. Dexamethasone treatment decreased the corticosterone response relative to all other groups. *, P < 0.05 vs. vehicle; #, P < 0.05 vs. dexamethasone.