Table 1.
Differentially expressed ECM and cell adhesion genes in preovulatory granulosa cells
| Gene | Description | Fold change (Inha−/−/WT) |
|---|---|---|
| Up in Inha−/− | ||
| Lamc3 | Laminin-γ3 | +16.6 |
| Bcan | Brevican | +16.2 (+12.3a) |
| Mmp2 | Matrix metallopeptidase 2 | +9.8 (+26.5a) |
| Wisp1 | WNT1 inducible signaling pathway protein 1 | +9.5 (+9.5a) |
| Boc | Biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein | +8.8 |
| Col1a2 | Collagen, type I, α2 | +7.0 |
| Adamtsl2 | ADAMTS-like 2 | +5.1 |
| Emilin2 | Elastin microfibril interfacer 2 | +5.0 |
| Col4a4 | Collagen, type IV, α4 | +3.9 |
| Col3a1 | Collagen, type III, α1 | +3.5 |
| Itga9 | Integrin α9 | +3.5 |
| Gjc1 | Gap junction protein, γ1 | +2.8 |
| Col6a1 | Collagen, type VI, α1 | +2.7 |
| Matn2 | Matrilin 2 | +2.5 |
| Jam2 | Junction adhesion molecule 2 | +2.4 |
| Down in Inha−/− | ||
| Coch | Coagulation factor C homolog (Limulus polyphemus) | −64.7 |
| Comp | Cartilage oligomeric matrix protein | −46.9 (−38.3a) |
| Cyr61 | Cysteine-rich protein 61 | −13.0 |
| Ctgf | Connective tissue growth factor | −8.2 (−6.1a) |
| Col4a6 | Collagen, type IV, α6 | −6.7 |
| Prss23 | Protease, serine, 23 | −4.7 |
| Col4a5 | Collagen, type IV, α5 | −3.7 |
| Itga3 | Integrin α3 | −3.3 |
Genes in bold were independently validated by qPCR with fold change in parentheses.
a
qPCR statistical significance at P < 0.05.