Table 1.

List of selected genes differentially expressed during microarray analysis in 4HPR-induced neuronal differentiation of human RPE cells^a

Symbol	Gene Name	Gene Function	Fold Change
Down-regulated genes
MME	Membrane-metallo-endopep	cell-cell signaling, proteolysis	−18
IGFBP5	Insulin-like growth factor BP	cell growth, signal transduction	−16
LEPR	Leptin receptor	energy metabolism, development	−4
GAS6	Growth-arrest-specific 6	cell proliferation, signal transduction	−2
COL11A1	Collagen, type X1, α1	cell-cell adhesion, organization	−2
INSIG1	Insulin-induced gene 1	cell proliferation, metabolism	−2
Up-regulated genes
IL-8	Interleukin 8	cell cycle arrest, proliferation	27
HSPA1A	Heat Shock 70kDa	heat shock response	13
GPX3	Glutathione peroxidase	response to lipid hydroperoxide	8
ABCA1	ATP-binding cassette-1	phagocytosis, cholesterol metabolism	8
DHRS3	Dehydrogenase/reductase	fatty acid metabolism, vision	7
GLRX	Glutaredoxin	electron transport	6
HMOX1	Heme oxygenase 1	heme oxidation	5
IGFBP6	Insulin-like growth factor BP	cell growth, proliferation	4
EDF1	Endothelial differentiation F1	cell growth/ or maintenance	3
FABP5	Fatty acid binding protein 5	epidermal differentiation, transport	2
TIMP1	Tissue inhibitor of MP 1	cell proliferation, proteolysis	2

^aARPE-19 cells in culture were treated with 1 µM of 4HPR for 72 h. Total RNA was isolated from control and treated cells, and gene expression was analyzed using the GeneChip Human Genome U133 Plus 2.0 array (Affymetrix).