Figure 6.

Dopamine release to pellet delivery increases with escalating costs. A, Examples of dopamine release in the NAcc core to food pellet delivery in progressively later trials in a PR session. Current at the peak oxidation potential of dopamine is plotted as a function of time, with the inset showing the cyclic voltammogram identifying the detected current as dopamine. Below are two-dimensional pseudocolor plots of cyclic voltammograms over time. Rectangular dashed lines denote the pellet delivery. B, C, Peak dopamine response to pellet delivery increased with higher costs in both the NAcc core (n = 13; B) and NAcc shell (n = 9; C).