Table 1.
Baseline values for height, weight and pulmonary function parameters in SHIV/Pc− and SHIV/Pc+ animals.
| Parameter | Pc negative* | Pc positive | p value |
|---|---|---|---|
| Height, cm | 58.4 (53.3 – 61.0) | 61.0 (45.7 – 63.5) | 0.94 |
| Weight, kg | 4.7 (3.3 – 5.8) | 5.8 (3.8 – 7.6) | 0.19 |
| Pulmonary Function Parameters† | |||
| FEV0.1, ml | 39.1 (36.6 – 42.6) | 37.3 (32.9 – 44.8) | 0.66 |
| FEV0.2, ml | 89.4 (86.2 – 96.7) | 88.4 (77.3 – 101.2) | 0.80 |
| FEV0.4, ml | 187.2 (168.4–197.9) | 186.2 (163.6 – 204.4) | 0.97 |
| FVC, ml | 396.7 (223.8 – 454.6) | 415.9 (227.8 – 527.8) | 0.61 |
| FEV0.1/FVC, % | 10.4 (8.0 – 17.2) | 8.4 (7.2 – 19.7) | 0.74 |
| FEV0.2/FVC, % | 23.8 (19.0 – 38.6) | 19.9 (16.8 – 44.4) | 0.77 |
| FEV0.4/FVC, % | 49.3 (39.8 – 75.3) | 42.0 (35.3 – 85.4) | 0.78 |
| FEF25%, ml/s | 504.7 (483.6 – 527.5) | 497.3 (438.6 – 572.6) | 0.95 |
| FEF50%, ml/s | 453.9 (430.6 – 483.0) | 456.2 (404.1 – 542.7) | 0.72 |
| FEF75%, ml/s | 382.2 (349.8 – 430.6) | 391.7 (367.3 – 477.0) | 0.36 |
| FEF90%, ml/s | 230.8 (180.7 – 376.2) | 299.1 (170.8 – 370.5) | 0.53 |
| FEF25–75%, ml/s (MMEF) | 450.5 (423.3 – 480.6) | 450.6 (402.3 – 535.6) | 0.71 |
| PEF, ml/s | 517.7 (492.9 – 546.8) | 512.7 (447.1 – 576.2) | 0.89 |
Comparison of baseline values of animals that were subsequently infected with SHIV89.6P and were colonized with Pc (SHIV/Pc+, n = 8) or remained uncolonized (SHIV/Pc−, n = 4). No significant differences were observed in any of the parameters by unpaired t test.
FEV0.1, FEV0.2, FEV0.4, forced expiratory volume in 0.1, 0.2 and 0.4 seconds respectively; FVC, forced vital capacity; FEF25%, FEF50%, FEF75%, FEF90%, forced expiratory flow through 25%, 50%, 75% and 90% of forced vital capacity respectively; FEF25–75% (MMEF), forced expiratory flow from 25% to 75% of forced vital capacity or maximum mid-expiratory flow; PEF, peak expiratory flow. Values are medians with ranges shown in parentheses.