Table 1.
Genes associated with repression of mutacin I production
| # | Oralgen ID/GenBank tag (# of hit) | Annotation | Functional class |
|---|---|---|---|
| Class 1 mutant | |||
| 1 | SMu0557/SMU.611 (1) | DeaD, ATP dependent RNA helicase | Transcription, degradation of RNA |
| 2 | SMu0797/SMU.874 (1) | metH, 5-methyltetrahydrofolate-homocysteine methyltransferase | Amino acid biosynthesis, central intermediate metabolism, one carbon metabolism |
| 3 | SMu859/SMU.947 (1) | Dfr, dhfr, dyr, dihydrofolate reductase | Biosynthesis of cofactors, prothetic groups and carriers, folic acid |
| 4 | SMu1034/SMU.1132 (8) | pepN, lysyl-aminopeptidase | Degradation of proteins, peptides |
| 5 | SMu1849/SMU2035 (2) | mccF, possible bacteriocin immunity protein | Toxin production and resistance |
| 6 | SMu1850/SMU.2036 (2) | pepO, endopeptidase O | Degradation of proteins |
| 7 | SMu1885/SMU.2077 (2) | conserved hypothetical protein | unknown |
| Class 2 mutant | |||
| 8 | SMu0432/SMU.478 (1) | kguA, guanylate kinase | Purine metabolism |
| 9 | SMu0617/SMU.675 (1) | ptsI, phosphoenolpyruvate-protein phosphotransferase (enzyme I) | Signal transduction, PTS |
| 10 | SMu0646/SMU.707 (2) | endolysin | Biosynthesis & degradation of murein sacculus and peptidoglycan |
| 11 | SMu0649/SMU.712 (1) | Ppc/pepC, phosphoenolpyruvate carboxylase | Central intermediate metabolism |
| Class 3 mutant | |||
| 12 | SMu0538/SMU.591 (1) | HTP, upstream is a transcription regulator sharing IGS with furR | unknown |
| 13 | SMu0727/SMU.801 (1) | Obg, GTP-binding protein, GTP1/Obg family | unassigned |
| 14 | SMu1319/SMU.1449 (1) | fbp, pavA, fibrinogen-binding protein-A | Cellular process, pathogenesis, transport and binding proteins |
| 15 | SMu1708/SMU.1878 (1) | manM, mannose PTS system component IIC, a membrane protein | Signal transduction, PTS |
| 16 | SMu1709/SMU.1879 (7) | manN, mannose PTS system component IID, a membrane protein | Signal transduction, PTS |
| 17 | SMu1848/SMU.2033 (1) | conserved hypothetical protein | unknown |