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Examples of ubiquitin chain remodeling. A20 mediates de-ubiquitination of Lys63 poly-ubiquitinated RIP-1. A20 can also catalyze the Lys48 poly-ubiquitination of RIP-1. At the proteasome the actions of de-ubiquitinating enzymes and E3-ligases can prevent a substrate from proteasome degradation, or extend the poly-ubiquitin chain and therefore enhance degradation.
