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. Author manuscript; available in PMC: 2010 Sep 27.
Published in final edited form as: Neuroscientist. 2009 Jan 30;15(3):243–260. doi: 10.1177/1073858408327809

Figure 6.

Figure 6

Overview of preconditioning ischemia mediated morphological re-organization in dendrite and alterations in NMDA receptor mediated signaling. Following preconditioning ischemia, protein degradation and actin re-organization result in uncoupling of the NMDA receptor complexes from the actin cytoskeleton. The morphological and cytoskeleton changes results in an uncoupling of the toxic NMDA receptor mediated signaling but not physiological NMDA receptor function. As a result NMDA mediated excitotoxicity is reduced following preconditioning ischemia. This result may help identify how to switch off harmful NMDA receptor mediated signaling.