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. Author manuscript; available in PMC: 2010 Sep 27.
Published in final edited form as: Nutr Cancer. 2009;61(5):746–753. doi: 10.1080/01635580902825597

Figure 5. Inhibition of PKC inhibited stearate-induced caspase-3 activity at 12 hours.

Figure 5

A) Hs578t cells were treated with 50 μM stearate for the times indicated, lysates were collected and immunoblotted with a pan phospho-PKC antibody. Stearate induced phosphorylation of PKC 1-3 hours post treatment (n=4). B) Hs578t cells were treated with the pan PKC inhibitor GF-109203X for 1 hour prior to treatment with 50 μM stearate. Inhibition of PKC blocked stearate-induced caspase-3 activity (n=5; * different compared to stearate treated controls p<0.02 but not different from non-stearate treated controls p>0.07 by the paired t-test).