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. Author manuscript; available in PMC: 2010 Sep 27.
Published in final edited form as: Nature. 2009 Apr 9;458(7239):776–779. doi: 10.1038/nature07737

Figure 2. The presence of constitutively active Smo increases the frequency of CML stem cells and accelerates disease.

Figure 2

a, Analysis of YFP fluorescence, which reflects SmoM2 expression in control (con) and SmoM2 KLSF cells (n = 4). b, Analysis of CML stem cells (GFP+ KLS) in mice transplanted with BCR–ABL1-infected control (left) and constitutively activated Smo (SmoM2, right) KLSF cells. c, The average percentage of CML stem cells in mice receiving BCR–ABL1-transduced control (n = 4) and SmoM2 KLSF cells (n = 12). Error bars are s.e.m., *P = 0.048. d, rtPCR analysis of SmoM2 expression in CML stem cells. e, Survival curve of mice receiving BCR–ABL1 transduced control (solid line) or SmoM2 KLSF cells (dashed line; n = 2, 16 mice, P = 0.0082).