Figure 1.
Natural history of Type 1 Diabetes with molecular, cellular and metabolic events during disease progression. All T1D patients probably have a genetic predisposition that does not change over time. The appearance of islet autoantibodies mark two important transitions, one being from AbN to AbP, and the other being from AbP to T1D. Molecular and cellular events associated with these transitions may serve as T1D biomarkers.