Table 1.
Summary of T1D genomic intervals identified by genetic mapping studies
| WTCCC | Todd et al. 2007 |
Barrett et al. 2009 | Other Studies | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr. | Gene of interest |
P-value | OR | P-value | OR | P-value | OR | P-value | OR | Ref |
| rs2476601 | 1p13.2 | PTPN22 | 1.7E-32 | 2.04 | 8.5E-85 | 8.7E-4 | 1.32 | (26) | |||
| rs2269241 | 1p31.3 | PGM1 | 5.9E-6 | 1.10 | |||||||
| rs3024505 | 1q32.1 | IL10 | 2.2E-6 | 0.84 | |||||||
| rs2816316 | 1q31.2 | RGS1 | 3.1E-5 | ||||||||
| rs1990760 | 2q24.2 | IFIH1 | 1.4E-10 | 0.86 | 3.8E-3 | 0.89 | 6.6E-9 | 0.027 | 0.849 | (26) | |
| rs1534422 | 2p25.1 | NA | 6.7E-6 | 1.08 | |||||||
| rs3087243 | 2q33.2 | CTLA4 | 1.2E-15 | 0.02 | 1.191 | (26) | |||||
| rs11711054 | 3p21.31 | CCR5 | 1.7E-5 | ||||||||
| rs1051708 | 4p15.2 | NA | 2.8E-7 | ||||||||
| rs4505848 | 4q27 | IL2 | 6.3E-7 | 1.27 | 4.7E-13 | ||||||
| rs6897932 | 5p13.2 | IL7R | 0.095 | 0.93 | 0.026 | 6.9E-7 | 1.13 | (91) | |||
| rs9268645 | 6p21.32 | MHC | <10−100 | ||||||||
| rs11755527 | 6q15 | BACH2 | 5.4E-8 | 0.0075 | 1.216 | (26) | |||||
| rs9388489 | 6q22.32 | C6orf173 | 5.1E-8 | 1.17 | |||||||
| rs4948088 | 7p12.1 | COBL | 2.7E-6 | 0.77 | |||||||
| rs78043256 | 7p15.2 | NA | 3.3E-8 | 0.00051 | |||||||
| rs4729562 | 7q22 | LOC646282 | 8.8E-5 | 0.81 | (91) | ||||||
| rs7020673 | 9p24.2 | GLIS3 | 1.9E-9 | 0.88 | 2.9E-4 | 1.30 | (26) | ||||
| rs947474 | 10p15 | PRKCQ | 1.2E-7 | ||||||||
| rs1225130 | 10p15.1 | IL2RA | 1.3E-13 | 4.6E-4 | 1.30 | (26) | |||||
| rs10509540 | 10q23.31 | C10orf59 | 6.9E-9 | 0.75 | |||||||
| rs7111341 | 11p15.5 | INS | 4.4E-48 | 4.3E-9 | 0.622 | (26) | |||||
| rs3764021 | 12p13 | CLEC2D | 7.1E-5 | 0.64 | 0.0267 | 0.93 | |||||
| rs4763879 | 12p13.31 | CD69 | 2.8E-7 | 1.09 | |||||||
| rs773107 | 12q13 | SUOX, | 2.8E-5 | 1.25 | (27) | ||||||
| rs10876864 | 12q13 | ERBB3 | 8.3E-5 | 1.33 | (26) | ||||||
| rs1701704 | 12q13 | CDK2 | 9.8E-6 | 1.25 | (27) | ||||||
| rs2292239 | 12q13 | ERBB3 | 1.4E-9 | 0.77 | 1.8E-14 | 1.28 | 2.2E-25 | ||||
| rs17696736 | 12q24 | C12orf30 | 7.2E-14 | 1.37 | 1.8E-6 | 1.16 | 8.7E-8 | 0.86 | (91) | ||
| rs3184504 | 12q24.12 | SH2B3 | 2.8E-27 | ||||||||
| rs1465788 | 14q24.1 | NA | 1.4E-8 | 0.86 | |||||||
| rs941578 | 14q32.2 | DLK1 | 0.049 | 0.9 | 0.00042 | 1.09 | 9.8E-7 | 0.9 | (92) | ||
| rs3825932 | 15q24 | CTSH | 7.7E-8 | ||||||||
| rs4788084 | 16p11.2 | IL27 | 5.2E-8 | 0.86 | (91) | ||||||
| rs1244426 | 16p12.3 | NA | 2.0E-6 | 1.1 | |||||||
| rs12708716 | 16p13 | KIAA0350 | 1.28 × 10−8 | 0.77 | 7.07 × 10−9 |
0.83 | 2.2E-16 | 1.0E-6 | 0.63 | (26) | |
| rs7202877 | 16q23.1 | NA | 5.7E-11 | 1.28 | |||||||
| rs1695693 | 17p13.1 | NA | 3.2E-6 | 0.92 | |||||||
| rs2290400 | 17q12 | ORMDL3 | 1.3E-7 | 0.87 | |||||||
| rs7221109 | 17q21.2 | NA | 9.9E-8 | 0.95 | |||||||
| rs2542151 | 18p11 | PTPN2 | 8.4E-8 | 1.33 | 3.3E-10 | 1.29 | |||||
| rs1893217 | 18p11.21 | PTPN2 | 3.6E-15 | ||||||||
| rs763361 | 18q22 | CD226 | 1.5E-5 | 1.18 | 1.2E-5 | ||||||
| rs2304256 | 19p13.2 | TYK2 | 2.6E-3 | 0.84 | 1.4E-10 | 0.86 | (92) | ||||
| rs425105 | 19q13.32 | NA | 1.5E-7 | 0.86 | |||||||
| rs2281808 | 20p13 | NA | 5.0E-7 | 0.9 | |||||||
| rs2232613 | 20q11 | NA | 0.738 | 0.98 | 8.1E-5 | 1.11 | (91) | ||||
| rs5753037 | 22q12.2 | NA | 1.8E-14 | 1.1 | |||||||
| rs229541 | 22q13 | C1QTNF6 | 2.1E-7 | ||||||||
| rs2664170 | Xq28 | NA | 3.0E-5 | 1.16 | |||||||
NA-Not Available