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THBS4 methylation is associated with ageing in normal colorectal mucosa. A strong correlation was observed between THBS4 methylation (presented as the log transformed pancolorectal result) and age in the normal mucosa from the colonoscopy study (ρ = 0.50, P < 0.0001). Because of this strong relationship with aging, we have postulated that THBS4 is a Type A (age-related) marker of methylation.
