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. Author manuscript; available in PMC: 2010 Sep 27.
Published in final edited form as: J Stem Cells. 2010;5(1):23–31.

Table 1. Effects of chemokines and cytokines on adult NSCs.

Cytokine / Chemokine Effect on aNSCs Reference
IFN- γ Promotion of differentiation and neurite outgrowth. Reduction of proliferation and survival of multipotent progenitors. [39, 40, 42]
IGF-1 Increasing of neurogenesis in SGZ [43]
IL-4 Oligodendrogenesis [44]
LIF Neurogenesis promotions and NSC self-renewal (acute exposure) [15, 46, 47]
CNTF Neurogenesis promotions and NSC self-renewal (acute exposure) [15, 79]
Leptin Inhibition of differentiation of multipotent cells and glial progenitors [15, 61]
TNF- α Decreasing of neurogenesis [11]
H-IL-6 Differentiation into glutamate-responsive neurons and oligodendrocytes [62]
MCP-1 Migration of NSCs [37, 38]
SDF-1 Promotion of migration, survival and proliferation of NSCs [37, 70, 71, 73]
CCL2 Neuronal differentiation of SVZ progenitors [74]