Table 1.
All Patients | Site 1 | Site 2 | Site 3 | Site 4 | Site 5 | |
---|---|---|---|---|---|---|
Thalassemia major | 43 | 10 | 10 | 9 | 10 | 4 |
BThal/HbE | 6 | 0 | 0 | 0 | 0 | 6 |
Male | 17 | 3 | 4 | 2 | 5 | 3 |
Female | 32 | 7 | 6 | 7 | 5 | 7 |
Age [years] | 30.9 +/− 8.8 | 38.3 +/− 4.4 | 27.7 +/− 3.7 | 35.4 +/− 10.5 | 22.0 +/− 3.5 | 31.3 +/− 9.5 |
Mean Myocardial T2* +/− SD | 24.9 +/− 14.9 | 24.5 +/− 12.5 | 13.7 +/− 6.4 | 34.2 +/− 12.9 | 25.0 +/− 19.1 | 28.2 +/− 15.1 |
Myocardial T2* range | 2.7 – 52.9 | 4.9 – 40.9 | 8.0 – 29.1 | 17.4 – 52.9 | 2.7 – 51.1 | 6.7 – 52.3 |
Mean Liver T2* +/− SD | 6.5 +/− 7.3 | 8.7 +/− 9.5 | 9.6 +/− 9.5 | 4.7 +/− 3.0 | 3.2 +/− 2.5 | N/A |
Liver T2* range | 0.5 – 26.2 | 1.1 – 26.2 | 0.5 – 23.0 | 2.3 – 11.8 | 0.8 – 7.5 | N/A |
Time between scans [days] | 20.1 +/− 19.0 | 12 | 2 | 56 | 26 | 8 |
History of heart Failure | 1 | 0 | 0 | 0 | 0 | 1 |
History of arrhythmia | 6 | 1 SVT | 1 AF,1 VT | 1 AF | 1 AF | 1 VT |
History of coronary or valvular disease | 0 | 0 | 0 | 0 | 0 | 0 |
Blood transfusions per year | 29.2 +/− 11.9 | 34.4 +/− 7.2 | 29.8 +/− 12.8 | 33.0 +/− 4.0 | 35.1 +/− 9.1 | 14.2 +/− 10.6 |
Serum ferritin ug/L | 2950 +/−3068 | 5025 +/− 3976 | 2369 +/− 2479 | 1705 +/− 1102 | 2799 +/− 2504 | 2728 +/− 3758 |
Deferoxamine | 16 | 0 | 2 | 5 | 5 | 4 |
Deferiprone | 4 | 1 | 0 | 2 | 1 | 0 |
Deferasirox | 3 | 0 | 1 | 2 | 0 | 0 |
Deferoxamine + deferiprone | 24 | 9 | 7 | 0 | 4 | 4 |
No Chelation | 2 | 0 | 0 | 0 | 0 | 2 |
Cardiac Medication | 6 | 2 | 2 | 0 | 1 | 1 |