. Author manuscript; available in PMC: 2010 Sep 28.

Published in final edited form as: Clin Infect Dis. 2009 Oct;49(7):1109–1116. doi: 10.1086/605594

Table 2.

Determinants of a first AIDS-defining malignancy, multivariate analyses including either cumulative exposure to viro-immunological markers or latest measurements (ANRS CO3 Aquitaine Cohort, 1998–2006; N = 4194; 107 cases)

Cumulative exposure^a,^b				Latest measurement^a,^b
Variables				Variables
Variables	HR	95% CI	p	Variables	HR	95% CI	p

CD4+ <200 cells/mm³ (per additional year of exposure)	1.36	[1.21 – 1.54]	<0.001	CD4+ <200 cells/mm³ (yes vs no)	6.33	[4.25 – 9.41]	<0.001
Plasma HIV RNA >500 copies/mL (per additional year of exposure)	1.27	[1.15 – 1.40]	<0.001	Plasma HIV RNA >500 copies/mL (yes vs no)	3.30	[2.07 – 5.25]	<0.001
cART exposure (per additional year)	0.82	[0.74 – 0.91]	<0.001	cART (yes vs no)	0.93	[0.61 – 1.43]	0.74
Gender (women vs men)	0.69	[0.43 – 1.10]	0.11	Gender (w vs m)	0.75	[0.47 – 1.19]	0.22

NOTE. HR, Hazard Ratio for the association between a given variable and hazard of AIDS-defining malignancy

CI, Confidence Interval

Adjusted for other variables: CD4+ <200, plasma HIV RNA >500, cART exposure and gender

Akaike criterion (AIC) for cumulative exposure = 1325.3, AIC for latest measurement = 1251.4