Skip to main content
. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Leukemia. 2010 Apr 1;24(5):976–985. doi: 10.1038/leu.2010.53

Figure 3. S1P is a major chemotactic component of plasma.

Figure 3

Panel A - Murine plasma S1P levels increase during mobilization (10 min after zymosan-, 1 h after AMD3100-, and 6 h at day 6 after the last G-CSF-treatment). Panel B and C - However, S1P does not chemoattract differentiated/mature BMNCs; (B), it strongly chemoattracts BM-residing naïve HSPCs (C). Panel D – S1P has much lower chemotactic activity against G-CSF-mobilized PB circulating HSPCs. Ctl, normal mouse plasma; M, media only control; SDF-1 (ng/ml). * p<0.01, ** p<0.001. The data shown represent the combined results from three independent experiments carried out in triplicate per group (n=9).