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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Leukemia. 2010 Apr 1;24(5):976–985. doi: 10.1038/leu.2010.53

Figure 5. The role of MAC in mobilization.

Figure 5

Panel A – Free hemoglobin level in plasma correlates with strength of CC activation. Panel B – MAC deposits are detectable in BM of G-CSF-mobilized wt but not C5−/− mice. Diffuse MAC deposition is visible in endothelial cells (arrow), osteoblasts (arrow head), and interstitium. Original magnification ×200. Panel C – Chemotactic response of BM CFU-GM to erythrocyte lysates prepared from plasma-washed erythrocytes followed by repeated freezing and thawing. Ctl, normal mouse plasma; M, media only control. * p<0.01, ** p<0.001. The data shown represent the combined results from three independent experiments carried out in triplicate per group (n=9).