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. Author manuscript; available in PMC: 2011 Jul 27.
Published in final edited form as: Curr Biol. 2010 Jun 24;20(14):1321–1325. doi: 10.1016/j.cub.2010.05.062

Table 2.

Summary of hub genes and synthetic interactions with developmental pathways

gene descriptiona Enhancement with developmental
regulatory componentsb
din-1 ortholog of human transcriptional co-repressor
SHARP/SPEN, encodes large RNA-binding protein of
RRM superfamily		 EGF, Wnt, Notch, ephrin receptor
dpy-22 ortholog of the human transcriptional Mediator protein
TRAP230		 EGF, Wnt, Notch, E2F/synMuvB,
ephrin receptor, RAC1/GTPase
egl-27 ortholog of human MTA1, part of nucleosome
remodelling and histone deacetylation (NURD)
complex		 EGF, Notch, E2F/synMuvB,
ephrin receptor
hmg-1.2 DNA binding protein with HMG box EGF, Wnt, Notch, ephrin receptor
trr-1 Ortholog of component of the NuA4/Tip60 histone
acetyltransferase complexes,atypical protein kinase of
TRAAP subfamily		 EGF, Wnt, Notch, E2F/synMuvB,
GTPase
a

information from www.wormbase.org

b

see [3] for details