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. 2010 Sep 27;5(9):e13017. doi: 10.1371/journal.pone.0013017

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Nishino et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Expression patterns of representative genes. RT-PCR analysis of 7 representative genes and methyltransferase genes. Methylation levels (Me) of each promoter are shown under each panel. H = High methylation (0.7<score); M = Middle methylation (0.3<score≤0.7); L = Low methylation (score≤0.3). (B) Comparable distribution of the SS-DMR and histone trimethylation (me3) of H3K4 and H3K27. Percentage of H3K4me3, H3K27me3, bivalent H3K4me3/K27me3 or non-modification on genes in SS-hyper-DMRs and in SS-hypo-DMRs. (C) Histone modification of 23 genes in Table 3.