Table 3.

Diplotypes

		MI n=1063/3462		Isch Stroke n=469/3462		Hem Stroke n=91/3462		VT n=504/2172
Diplotype Category†	pop freqs	OR* (95% CI)	p- value	OR* (95% CI)	p- value	OR* (95% CI)	p- value	OR* (95% CI)	p- value
O1O1	0.42	ref	ref	ref	ref	ref	ref	ref	ref
O1O2	0.03	1.10 (0.73–1.65)	0.660	1.11 (0.61–2.01)	0.737	1.65 (0.57–4.76)	0.351	0.64 (0.28–1.48)	0.295
A11	0.32	1.23 (1.05–1.44)	0.012	1.01 (0.80–1.28)	0.906	0.91 (0.55–1.51)	0.722	1.79 (1.41–2.26)	<0.001
A2	0.10	0.81 (0.63–1.06)	0.125	1.07 (0.76–1.51)	0.711	0.82 (0.38–1.78)	0.616	1.28 (0.89–1.85)	0.182
B	0.10	1.17 (0.92–1.49)	0.191	1.59 (1.17–2.17)	0.003	1.43 (0.73–2.79)	0.295	1.82 (1.29–2.57)	0.001
AB	0.04	0.80 (0.52–1.23)	0.312	0.93 (0.52–1.65)	0.793	0.60 (0.14–2.56)	0.488	2.70 (1.73–4.21)	<0.001

^*Adjusted for age, sex, treated hypertension, index year, and race

^†

Diplotype categories are defined as the following groups of diplotypes:

• O¹O¹ = O¹¹O¹¹, O¹¹O¹², or O¹²O¹²
• O¹O² = O¹¹O² or O¹²O²
• A¹¹ = A¹¹A¹¹, A¹¹A², A¹¹O¹¹, A¹¹O¹², or A¹¹O²
• A² = A²A², A²O¹¹, A²O¹², or A²O²
• B = BB, BO¹¹, BO¹², or BO²
• AB = A¹¹B or A²B

where A² refers to the haplotype coding for the A¹² or A² alleles