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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2010 Aug 3;248(2):100–110. doi: 10.1016/j.taap.2010.07.013

Figure 3. Acrolein exposure increases platelet-fibrinogen binding.

Figure 3

Panel A showsflow cytometric analysis of platelet-fibrinogen binding ex vivo in whole blood in mice following sub chronic exposure to acrolein (1 ppm for 6h/day for four days; n=6) or filtered air (n=6). For these assays PE-labeled anti-CD41 and FITC labeled fibrinogen were used. Forward scatter (FSC) and side scatter (SSC) of cells were used to distinguish platelets from other cells and cell debris. Panel B shows group data, presented as mean ± SEM of fluorescence intensity (arbitrary units) of fibrinogen bound to CD41-positive platelets (i) and surface expression of CD41(ii). §P ≤ 0.02 versus control.