Skip to main content
. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2010 Aug 3;248(2):100–110. doi: 10.1016/j.taap.2010.07.013

Figure 7. Oral exposure to acrolein promotes platelet aggregation.

Figure 7

Panel A shows representative tracings of ADP-induced platelet aggregation in washed platelets in mice following different doses of acute oral exposure of acrolein (Ai; 1-5 mg/kg by gavage; n=8). Mice gavage-fed with water served as controls (n=8). Panel Aii shows ADP-induced platelet aggregation in washed platelets of mice exposed to acrolein (5 mg/kg) after 24 h. Inset shows the protein-acrolein adduct formation in the washed platelets of acrolein (5 mg/kg) - fed mice. Panel B shows the group data of platelet-leukocyte aggregate formation in the whole blood of acrolein (5mg/kg, 24 h; n=6) - exposed mice. Panel C shows the levels of PF4 in the plasma of acrolein (5 mg/kg, 24 h; n=8) exposed mice. Panel D shows the effect of oral exposure to acrolein (5 mg/kg, 24 h; n=6) on tail bleeding time.