Table 1.
Parameters measured in C57BL/6 mice exposed to air or acrolein.
| Acute | Sub-Chronic | |||
|---|---|---|---|---|
| Air | Acrolein (5ppm for 6h) |
Air | Acrolein (1ppm, 6h/day for 4 days) |
|
| Blood | ||||
| Cholesterola | 97±4 | 90±2 | 117±4 | 101±6* |
| HDLa | 73±3 | 68±2 | 88±3 | 69±5* |
| LDLa | 18±1 | 15±1 | 23±2 | 29±3 |
| Triglyceridesa | 28±3 | 27±3 | 38±5 | 20±4* |
| TPb | 4.81±0.06 | 4.61±0.05* | 4.99±0.18 | 4.97±0.12 |
| ALBb | 3.05±0.05 | 2.94±0.04 | 3.19±0.03 | 3.18±0.04 |
| LDHc | 165±16 | 154±13 | 181±11 | 202±17 |
| CKc | 164±11 | 202±34 | 166±22 | 196±22 |
| ALTc | 19±2 | 19±2 | 20±2 | 20±2 |
| ASTc | 56±2 | 62±6 | 48±6 | 62±6 |
| Lung | ||||
| TNF-αd | 1±0.08 | 1.01±0.15 | 1±0.16 | 0.84±0.18 |
| IL1-βd | 1±0.24 | 0.67±0.18 | 1±0.48 | 0.69±0.17 |
| IL-6d | 1±0.14 | 0.68±0.13 | 1±0.32 | 1.25±0.36 |
| MCP-1d | 1±0.21 | 1.46±0.30 | 1±0.17 | 0.91±0.19 |
| CSF-2d | 1±0.22 | 0.91±0.25 | 1±0.01 | 0.81±0.07 |
| MDAe | 0.35±0.03 | 0.43±0.07 | 0.38±0.07 | 0.43±0.03 |
Male, 12-14 week old mice were exposed to filtered air or acrolein. Mice were euthanized immediately after exposure. Units,
a
- mg/dL;
b
- g/L;
c
- units/L;
d
Values for TNF-α, IL-1β, IL-6, MCP-1 and CSF-2 are expressed as fold change;
e
p moles/mg tissue weight.
Values are mean ± SEM.
*
P<0.05 vs. air-exposed controls; n=6–8 mice/group.
Abbreviations: HDL, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; TP, total protein; ALB, albumin; LDH, lactate dehydrogenase; CK, creatine kinase; ALT, alanine aminotransferase; AST, aspartate aminotransferase.