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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Arthritis Rheum. 2010 Sep;62(9):2680–2687. doi: 10.1002/art.27577

Figure 2.

Figure 2

SZP immunolocalization was observed in all samples at the articular surface regardless of OA severity. Histochemistry (H&E staining) revealed cell and proteoglycan patterns through the cartilage thickness that depended on OA severity. A, Samples from representative OA and normal subjects revealed the presence of SZP on exposed articular surfaces. SZP in OA samples was bound to the lamina splendens in locations LA and LP, and was observed in several cell layers into the tissue at MA and MP locations. SZP in normal samples was consistently observed in several cell layers into the tissue at MA location compared to other locations. B, From the OA study group, SZP was observed on the articular surface of samples representing the most severe OA (MA location) and minimal OA (LP location). C, In human allograft cartilage, SZP localized deeper into the tissue in the anterior location compared to the posterior location.