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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Int J Cancer. 2010 Nov 15;127(10):2478–2485. doi: 10.1002/ijc.25431

Figure 4. Effect of calorie restriction or DON on VM-M3 tumor growth and metastasis.

Figure 4

(A) Mice were implanted s.c. with the VM-M3/Fluc tumor as described in Materials and Methods. Mice were sacrificed 15–19 days post implantation and the tumors removed and weighed. The asterisks indicate that the CR or DON values differ significantly from the AL control group at p < 0.01. The ‡ indicates that the DON values differ significantly from the CR values at a p < 0.01. (B) At the time of sacrifice, the organs were removed and imaged ex vivo. Bioluminescence values were plotted on a log scale. All values represent the mean ± SEM of 6 to 24 mice per group. No detectable bioluminescence was found in the lung, liver or kidney of DON treated mice.