Table One.
Clinical features of long term survivors of amyotrophic lateral sclerosis in Olmsted County (1925–2004)
| Age at Onset /Sex |
First Symptoms | Time from Symptom Onset to Diagnosis of ALS (months) |
Time from Symptom Onset to first Bulbar Symptoms (months) |
UMN or LMN symptoms at presentation |
El Escorial Category at Time of Diagnosis |
Clinical Presentation |
Survival from Symptom Onset (months) |
|---|---|---|---|---|---|---|---|
| 51F | Speech Difficulty | 16 | 0 | UMN | Did not meet criteria |
Bulbar Palsy |
82 |
| 74F | Bilateral UE weakness, wasting |
22 | No bulbar symptoms |
LMN | Suspected | Flail Limb | 67 |
| 56M | Right UE weakness, pain |
9 | U/A | LMN | Probable | Flail Limb | 113 |
| 51M | Hand weakness | 38 | 53 | LMN | Probable | Typical Limb-Onset ALS |
75 |
| 39M | Bilateral Hand Weakness |
9 | 19 | LMN | Possible | Typical Limb-Onset ALS |
70 |
| 69F | Hand weakness and atrophy |
1 | 40 | LMN | Probable | Typical Limb-Onset ALS |
79 |
| 49M | Leg stiffness | 25 | 52 | LMN+UMN | Probable | Typical Limb-Onset ALS |
94 |
| 58M | UE weakness | 10 | 57 | LMN+UMN | Probable | Typical Limb-Onset ALS |
114 |
| 75M | Bilateral UE fasciculations |
52 | 100 | LMN | Did not meet criteria |
Progressive Muscular Atrophy |
106 |
| 58M | Dysarthria | 45 | 0 | LMN+UMN | Did not meet criteria |
Bulbar Palsy | 94 |
| 74F | UE weakness | 37 | 89 | LMN+UMN | Probable | Flail Limb | 93 |
| 64M | Foot drop | 7 | 29 | LMN+UMN | Did not meet criteria |
Typical Limb-Onset ALS |
65 |
| 49F | UE weakness, cramps, fasciculations |
8 | 10 | LMN+UMN | Did not meet criteria |
Typical Limb-Onset ALS |
62 |