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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: J Antibiot (Tokyo). 2010 Jul 21;63(9):539–544. doi: 10.1038/ja.2010.77

Table 1.

Key structural features and spectroscopic properties of macrocyclic trichothecenes.

Structural Feature Spectroscopic Properties
Epoxide across positions C-12 to C-13 Two prominent doublets (H-13a and H-13b) in the 1H NMR spectrum (e.g. δ 3.10 and 2.78; J = 4 Hz).
Double bond across positions C-9 to C-10 Prominent broad doublet (with possible allylic coupling at higher field) in 1H NMR spectrum for H-10 (e.g. δ 5.45).
Vinyl methyl group at position C-16 Prominent singlet (with possible allylic coupling at higher field) in 1H NMR spectrum (e.g. δ 1.73).
Two α,β-unsaturated lactone moieties at positions C-6' to C-11' [e.g. compounds similar to verrucarin A (1)]. Prominent UV spectrum with a single maximum (λ ~ 260 nm).
Additional α,β-unsaturated lactone moieties at positions C-1' to C-3' [e.g. compounds similar to roridin E (2)]. Prominent UV spectrum with two maxima (λ ~ 260 and 230 nm).