Figure 2.

T2-relaxometry procedures, which quantify free water content, indicate neural injury or failed development of neurons in CCHS children; alterations appear in the cerebellum, a column extending from the preoptic areas through the hypothalamus, the cingulate cortex, medial prefrontal cortex, and hippocampus. Specific functions related to physiological deficits in CCHS are noted for the structures; the functions represent only selected actions served by those structures. Adapted from Kumar et al. 2005, reproduced with permission.