Figure 7.

DTI and fMRI images of structural injury (yellow areas), as assessed by axial and radial diffusivity, and functional deficits (blue areas; both blue and yellow areas are highlighted with circles to show comparable regions in structural and functional panels) for hypercapnic, hypoxic, and cold pressor challenges in CCHS patients. Structural injury and functional deficits appear in cerebellum, lateral medulla, and a region of tissue extending from the posterior thalamus through the midbrain. Adopted from Harper et al. (2005), Kumar et al. (2008b), Macey et al. (2005a, b), reproduced with permission.