Table 2.
Relative risks (95% confidence intervals) of SCD according to categories of total alcohol intake
| Categories of alcohol intake (g/day)* | P-trend | |||||||
|---|---|---|---|---|---|---|---|---|
| abstainers | Former drinkers | 0.1-4.9 | 5.0-14.9 | 15.0-29.9 | 30.0+ | linear | quadratic | |
| Median alcohol intake (g/day) | 0 | 0 | 1.8 | 9.5 | 18.8 | 36.9 | ||
| cases | 108 | 46 | 70 | 36 | 13 | 22 | ||
| Person-years | 563903 | 282569 | 682411 | 432246 | 143572 | 97271 | ||
| IR (per 100,000 py) | 19 | 16 | 10 | 8 | 9 | 23 | ||
| Age, calorie adjusted | 1.0 (ref) | 0.63 (0.45-0.90) | 0.60 (0.44-0.81) | 0.47 (0.32-0.69) | 0.49 (0.27-0.87) | 1.19 (0.75-1.89) | 0.83 | <0.001 |
| Multivariate model 1† | 1.0 (ref) | 0.78 (0.54-1.12) | 0.67 (0.49-0.91) | 0.54 (0.36-0.80) | 0.58 (0.32-1.05) | 1.01 (0.62-1.64) | 0.86 | 0.002 |
| Multivariate model 2‡ | 1.0 (ref) | 0.79 (0.55-1.14) | 0.77 (0.57-1.06) | 0.64 (0.43-0.95) | 0.68 (0.38-1.23) | 1.15 (0.70-1.87) | 0.7 | 0.02 |
One drink is ~15 grams of alcohol
Multivariate model 1 adjusted for age (months), calories (continuous), smoking (5 categories), BMI (<25, 25-29.9, 30+ kg/m2), parental history of MI (no, < 60 years, ≥60 years), menopausal status (yes/no), use of postmenopausal hormones (current, past, never), aspirin use <1, 1-6 or ≥7 per week), multivitamin and vitamin E supplements (yes/no), physical activity (hours/week) and intake of marine omega-3 fat, alpha-linolenic fat, trans fat, and ratio of polyunsaturated to saturated fat (all in quintiles)
Multivariate model 2 further adjusted for diagnosis of CHD, stroke, diabetes, high blood pressure or high cholesterol.