Table 3.

Relative risks (95% confidence intervals) of nonfatal MI and non-sudden fatal CHD according to categories of total alcohol intake

	Categories of alcohol intake (g/day)*						P-trend
	abstainers	Former drinkers	0.1-4.9	5.0-14.9	15.0-29.9	30.0+	linear	quadratic
Median alcohol intake (g/day)	0	0	1.8	9.5	18.8	36.9
Nonfatal MI
Cases	645	395	625	350	94	86
Multivariate model 1†	1.0 (ref)	0.95 (0.84-1.08)	0.85 (0.76-0.95)	0.69 (0.61-0.79)	0.56 (0.45-0.69)	0.56 (0.44-0.71)	<0.001	<0.001
Multivariate model 2‡	1.0 (ref)	0.95 (0.84-1.08)	0.94 (0.84-1.05)	0.79 (0.69-0.91)	0.63 (0.50-0.79)	0.59 (0.46-0.75)	<0.001	0.09
Non-sudden fatal CHD
Cases	428	187	207	94	28	45
Multivariate model 1†	1.0 (ref)	1.00 (0.83-1.20)	0.56 (0.47-0.66)	0.38 (0.30-0.47)	0.35 (0.23-0.51)	0.54 (0.39-0.74)	<0.001	<0.001
Multivariate model 2‡,§	1.0 (ref)	1.05 (0.87-1.27)	0.71 (0.60-0.85)	0.52 (0.41-0.66)	0.49 (0.33-0.73)	0.69 (0.50-0.96)	<0.001	<0.001

^*One drink is approximately 15 grams of alcohol

^†Multivariate model 1 adjusted for age (months), calories (continuous), smoking (5 categories), BMI (<25, 25-29.9, 30+ kg/m²), parental history of MI (no, < 60 years, ≥60 years), menopausal status (yes/no), use of postmenopausal hormones (current, past, never), aspirin use <1, 1-6 or ≥7 per week), multivitamin and vitamin E supplements (yes/no), physical activity (hours/week) and intake of marine omega-3 fat, alpha-linolenic fat, trans fat, and ratio of polyunsaturated to saturated fat (all in quintiles)

^‡Multivariate model 2: further adjusted for diagnosis of stroke, diabetes, high blood pressure or high cholesterol.

^§Also adjusted for diagnosis of CHD