Table 2.
Oseltamivir Carboxylate (nM) |
Peramivir (nM) |
|||||||
---|---|---|---|---|---|---|---|---|
0 | 0.01 | 0.032 | 0.1 | 0.32 | 1.0 | 3.2 | 10 | |
10 | 7 ± 0.3a | 6 ± 0.5 | 6 ± 0.4 | 6 ± 0.9 | 5 ± 1.1 | 4 ± 0.4 | 2 ± 0.4 | 1 ± 0.2 |
3.2 | 18 ± 1.1 | 16 ± 1.3 | 15 ± 0.4 | 15 ± 1.3 | 12 ± 1.3 | 6 ± 0.2 | 2 ± 0.4 | 1 ± 0.1 |
1.0 | 39 ± 3.5 | 34 ± 2.8 | 33 ± 2.4 | 26 ± 2.7 | 15 ± 1.6 | 6 ± 0.6 | 2 ± 0.3 | 1 ± 0.2 |
0.32 | 65 ± 6.9 | 58 ± 6.5 | 55 ± 0.8 | 43 ± 4.4 | 18 ± 1.3 | 5 ± 0.5 | 2 ± 0.3 | 1 ± 0.2 |
0.1 | 88 ± 6.7 | 84 ± 4.6 | 72 ± 4.0 | 50 ± 3.6 | 18 ± 1.2 | 5 ± 0.5 | 2 ± 0.3 | 1 ± 0.2 |
0.032 | 99 ± 3.7 | 93 ± 9.1 | 78 ± 2.8 | 52 ± 7.1 | 23 ± 4.2 | 4 ± 1.0 | 2 ± 0.3 | 1 ± 0.3 |
0.01 | 103 ± 3.0 | 95 ± 4.1 | 79 ± 7.8 | 55 ± 6.8 | 18 ± 2.2 | 4 ± 0.2 | 2 ± 0.2 | 1 ± 0.9 |
0 | 100 ± 0.0 | 102 ± 5.1 | 87 ± 8.3 | 58 ± 6.6 | 21 ± 2.1 | 5 ± 0.4 | 2 ± 0.1 | 1 ± 0.2 |
Values are percentages of untreated control ± SD for three independent assays.