Table 3.
Survival results for the treatment of an influenza A/NWS/33 (H1N1) virus infection in mice with combinations of oseltamivir and peramivir. Intramuscular treatments with peramivir and oral treatments with oseltamivir were given twice a day for 5 days starting 2 hours prior to virus exposure.
| Survivors / Total (MDDa ± SD) |
||||||
|---|---|---|---|---|---|---|
| Peramivir, mg/kg/day |
||||||
| Oseltamivir Carboxylate, mg/kg/day |
0 | 0.05 | 0.1 | 0.2 | 0.4 | 1 |
| 1 | 7/10*** (14.1 ± 2.6**) |
- | - | - | - | - |
| 0.4 | 1/10 (11.0 ± 1.6***) |
1/9 (12.0 ± 2.1***) |
8/10***, ϕ (13.0 ± 4.2**) |
10/10*** | 10/10*** | - |
| 0.2 | 1/10 (9.8 ± 1.1**) |
0/10 (10.2 ± 0.6***) |
3/9* (16.5 ± 3.1***, ϕ) |
8/10*** (14.5 ± 2.1**) |
10/10*** | - |
| 0.1 | 0/10 (9.2 ± 0.6) |
0/10 (10.1 ± 0.9***) |
0/10 (11.3 ± 2.1***) |
7/10*** (12.3 ± 2.3**) |
9/10*** (10.0) |
- |
| 0.05 | 0/10 (9.2 ± 1.3) |
0/10 (10.2 ± 1.0***) |
1/10 (12.3 ± 3.9**) |
1/10ψ (12.3 ± 1.8***) |
10/10*** | - |
| 0 | 0/20 (8.7 ± 0.5) |
0/10 (9.4 ± 0.8*) |
1/10 (10.1 ± 1.5**) |
6/10*** (10.8 ± 1.5***) |
10/10*** | 10/10*** |
a
Mean day of death of mice that died prior to day 21 of the infection.
*
P<0.05,
**
P<0.01,
***
P<0.001, compared to placebo (oseltamivir - 0/peramivir - 0).
ϕ
P<0.05, compared to either compound alone.
ψ
P= 0.0573 (not quite significant), compared to peramivir alone.