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The mutant epidermal growth factor receptor, EGFRvIII, promotes cell survival and proliferation by preferential signaling through the phosphotidyinositol-3-kinase (PI3K) pathway. The wild-type receptor utilizes both the PI3K pathway and the Ras-Raf-MEK pathway. Downstream effectors of both pathways further promote cell survival via inhibition of apoptosis.
