Fig. 4.
Levels of oxidative damage to lipids and proteins are increased in PMs from brains of 3xTgAD mice compared with control mice. PM fractions isolated from the indicated brain regions were used to measure levels of isoprostanes (A), protein carbonyls (B) and nitrotyrosine (C). Values are the mean and SEM; n=6, by using pooled tissue from three mice per group. *p<0.01 compared with the value for WT. CTX, cerebral cortex; HIP, hippocampus; STR, striatum; CER, cerebellum; BS, brainstem.