Table 5.
Scores of hepatic steatosis, inflammation, and fibrosis staging
Group | Week | n | Steatosis score | Inflammation score | Fibrosis stage (n) | ||||
---|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | |||||
PFD | 41 | 0 | 0 | 29 | 0 | 0 | 0 | 0 | |
HFD | 4 | 12 | 1.67 ± 0.79* | 0 | 12 | 0 | 0 | 0 | 0 |
8 | 12 | 2.33 ± 0.65* | 0.3 ± 0.24 | 12 | 0 | 0 | 0 | 0 | |
12 | 12 | 2.75 ± 0.45* | 1.70 ± 0.77*, a | 12 | 0 | 0 | 0 | 0 | |
16 | 12 | 2.91 ± 0.29* | 2.57 ± 0.71*, b | 8 | 4 | 0 | 0 | 0 | |
24 | 9 | 2.67 ± 0.50* | 1.82 ± 0.60*, c | 0 | 3 | 3 | 2 | 1 | |
36 | 10 | 2.71 ± 0.61* | 1.93 ± 0.73*, c | 0 | 2 | 4 | 2 | 2 | |
48 | 10 | 2.65 ± 0.58* | 1.91 ± 0.69*, c | 0 | 1 | 4 | 3 | 2 |
In PFD groups at weeks 4, 8, 12, and 16, n = 6; at week 24, n = 5
In HFD groups at weeks 4, 8, 12, and 16, n = 12; at week 24, n = 9
HFD high-fat diet, PFD pair-fed diet
* P < 0.05 vs. PFD group
aP < 0.05 vs. weeks 4 and 8 HFD group
bP < 0.05 vs. week 12 HFD group
cP < 0.05 vs. week 16 HFD group