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. 2009 Dec 22;10(5):375–384. doi: 10.1038/tpj.2009.69

Figure 5.

Figure 5

Annotated phylogenetic tree shows that there are three groups of clades on the tree that have consistent and characteristic patterns of rs10524523 lengths (C1-C3). For the major clade B, which is associated with lower risk of LOAD and contains haplotypes linked to the APOE ɛ3 allele, rs10524523 lengths are characterized by a uniform short length (C1: mean=15.9, s.e.m.=0.4, n=63). There are two groups that branch from major clade A, one group is characterized by short lengths of rs10524523 (C2: mean length=21.4, s.e.m.=0.2, n=16) and the second by long rs10524523 lengths (C3: mean length=33.5, s.e.m.=0.3, n=30). Haplotypes in group C3 are linked uniquely to the APOE ɛ3 allele. The remaining subject haplotypes in clade A have a mean poly-T rs10524523 length of 30.2 (s.e.m.=0.3, n=101) and are associated with both APOE ɛ3 and ɛ4 alleles. There is a strong bootstrap support (973/1000) for the first major branch and moderate bootstrap support for the branches within clade A (247 of 1000 for C3 and 776 of 1000 for C2). Arrows indicate the branching point for each of the groups.