Table 3.
Kaplan-Meier results | Cox Proportional Hazards results | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
died | alive | probability of dying |
log rank p- value |
crude Hazard Ratio |
95% CI | p-value | adjust ed Hazard Ratio |
95%CI | p-value | |
Total | 32 | 222 | 14.0 | |||||||
Sex | ||||||||||
male | 18 | 114 | 14.7 | ref | ref | |||||
female | 14 | 108 | 13.2 | 0.547 | 0.81 | 0.40-1.62 | ||||
Age in months | ||||||||||
< 12 | 27 | 148 | 17.6 | 2.54 | 0.98-6.61 | 0.055 | 2.44 | 0.92-6.45 | 0.073 | |
≥ 12 | 5 | 74 | 6.4 | 0.047 | ref | ref | ref | ref | ||
Weight-for-age z-score a | ||||||||||
> −2 | 8 | 103 | 8.1 | |||||||
> −3 to −2 | 3 | 53 | 6.5 | |||||||
> −4 to −3 | 8 | 34 | 20.3 | |||||||
≤ −4 | 13 | 32 | 30.8 | 0.001 | 1.75 | 1.30-2.36 | 0.0002 | 1.61 | 1.19-2.19 | 0.002 |
HIV RNA in copies/ml * | ||||||||||
< 750,000 | 3 | 76 | 3.8 | ref | ref | ref | ref | |||
≥ 750,000 | 29 | 137 | 19.3 | 0.005 | 4.71 | 1.44- 15.48 |
0.011 | 3.22 | 0.97- 10.78 |
0.057 |
Pretreatment CD4% | ||||||||||
< 15 | 17 | 78 | 19.1 | 1.97 | 0.99-3.95 | 0.055 | 1.72 | 0.84-3.50 | 0.136 | |
≥ 15 | 15 | 144 | 11.1 | 0.051 | ref | ref | ref | ref | ||
TB treatment | ||||||||||
never | 16 | 139 | 11.2 | ref | ref | |||||
Start before ART | 8 | 54 | 13.9 | 1.10 | 0.47-2.56 | |||||
Start after ART | 8 | 29 | 22.4 | 0.321 | 1.88 | 0.80-4.41 |
in Cox proportional hazard analyses included as continues variable
9 children did not have a pre-treatment viral load