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. Author manuscript; available in PMC: 2011 Jul 30.
Published in final edited form as: Mol Cell. 2010 Jul 30;39(2):171–183. doi: 10.1016/j.molcel.2010.06.022

Table 1.

Enrichment of transcription factor binding elements in the promoters of mTORC1-induced genes.a

Transcription Factor Binding Motif Rap-Sensitive Probes (Total)c p-valued q-valuee
SREBP VNNVTCACCCYA 33 (82) 2.41E-07 1.28E-05
c-Myc (HIF1)b RACCACGTGCTC 385 (1164) 4.52E-06 1.45E-04
HNF4alpha VTGAACTTTGMMB 853 (2084) 2.17E-05 4.34E-04
ATF4 CVTGACGYMABG 18 (30) 5.57E-04 6.36E-03
a

Over-represented transcription factor-binding motifs in all rapamycin-sensitive genes from both Tsc1−/− and Tsc2−/− MEFs identified using a modified version of the MotifADE method (Mootha et al. 2004; Ma et al. 2008). Only these 4 motifs were in enriched in both cell lines with a q-value<0.01. Numbers for the Tsc2 null cells are provided.

b

The HIF1-binding hypoxia response element (bold) overlaps with this motif.

c

Numbers are based on 39,000 gene probes analyzed in triplicate with Affymetrix microarrays, comparing vehicle-treated versus rapamycin-treated (24 h) Tsc2−/− MEFs.

d

Two-tailed Mann-Whitney rank sum p-value.

e

Multiple testing corrected false discover rate (FDR) q-value.