Fig. 2.

Cumulative Change Analysis of Prednisone Dose

There was a trend toward separation between the placebo and POF groups in prednisone dose over the course of the study (p=0.053), as was determined via cumulative change analysis (34). Cumulative change analysis was used to compare the prednisone dose between the two arms. At each visit and for each group, all available dose changes from consecutive visits were averaged, and then these averages were aggregated over time. We included patients who had at least 3 months, ± 1 week, of data. There were 13 patients in the placebo group and 12 in the POF group. Virtually all subjects adhered to their prescribed treatment regimen, as determined by patient history and pill counts.