FIGURE 1.
Location of amino acid residues in NM23-H1 targeted by site-directed mutagenesis. (a) Shown is a three-dimensional surface model of the NM23-H1 hexamer, with one subunit represented in a ribbon format. Amino acid residues targeted by mutagenesis in this study are highlighted with a ball-and-stick format. Negative charges are identified in red and positive charges in blue . (b) The amino acid sequence of NM23-H1 is displayed in a linear alignment with secondary structure elements. Residues targeted by site-directed mutagenesis are underlined and highlighted in bold font.