. Author manuscript; available in PMC: 2012 Jan 1.

Published in final edited form as: Int J Cancer. 2011 Jan 1;128(1):40–50. doi: 10.1002/ijc.25307

TABLE III.

3’–5’ exonuclease activity of NM23-H1 is necessary for suppression of spontaneous metastasis of 1205lu melanoma cells.

1205Lu cell lines	Exogenous H1- mediated activities			Spontaneous metastases^†
	NDPK	HisK	EXO	%	(incidence)
parent		none		65^a	(17/26)
vector alone		none		60^a,b	(6/10)
Wild-type H1	+	+	+	25^c	(12/48)
E₅A	+	+	−	50^a,b	(13/26)
K₁₂Q	−	−	−	58^a,b	(14/24)
P₉₆S	+/−	+/−	+	25^c	(6/24)
H₁₁₈F	−	−	+	46^a^–c	(14/24)

^†

Spontaneous metastasis denotes lung metastases obtained from seeding by primary tumors derived from subcutaneous explantation of tumor cells. The number and size of macrometastases was not statistically different (p ≥ 0.05) between the cell lines as determined by the Mann-Whitney rank sum test. The apparent difference between H₁₁₈F and wild-type NM23-H1 nearly achieved statistical significance (p ≥ 0.07).

^a,b

Means not showing a common superscript are significantly different (p ≤ 0.01) as determined by Fisher’s exact test.

n.d., not determined