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. Author manuscript; available in PMC: 2010 Sep 28.
Published in final edited form as: Neuroimage. 2008 Oct 18;45(2):260–266. doi: 10.1016/j.neuroimage.2008.09.052

Figure 3. Abnormal metabolic covariance patterns in parkinsonian monkeys and PD patients.

Figure 3

A. Voxel-based SSM/PCA of high resolution FDG PET images from parkinsonian and healthy age-matched macaques. This analysis revealed a spatial covariance pattern (PC1, 25% VAF) that discriminated the two groups of animals (p<0.0005; see text). The pattern was characterized by positive metabolic contributions from pallidothalamic, pontocerebellar and motor cortical regions, and negative contributions from the posterior parietal cortex.

B. This abnormal primate covariance pattern resembles the PDRP topography that has been observed consistently in human subjects with PD (e.g., Ma et al., 2007; cf. Moeller et al., 1999; Eckert et al., 2007). [Both spatial covariance patterns were displayed on standard MRI brain templates. Voxels with positive region weights are color-coded from red to yellow; those with negative region weights are color-coded from blue to purple].