Table 1.

Regions with abnormal increases in glucose metabolism in early stage PD

Regions		Coordinatesa			Zmax	p-valueb	Glucose Metabolismc
							Absoluted		Normalizede
		x	y	z			PD	Normal	PD	Normal
Sensorimotor cortex	Right	14	−26	52	5.40	<0.001	10.71 ± 2.99	9.70 ± 2.91	1.59 ± 0.08	1.39 ± 0.13
	Left	−38	−26	52	4.37	0.004	12.24 ± 3.71	11.46 ± 3.44	1.81 ± 0.11	1.65 ± 0.12
Ventral thalamus	Left	−16	−24	6	4.68	0.012	12.00 ± 3.60	11.10 ± 3.22	1.77 ± 0.10	1.60 ± 0.13
	Right	22	−30	2	4.60	0.011	10.29 ± 3.03	9.49 ± 3.00	1.52 ± 0.06	1.36 ± 0.15
Putamen, GP	Right	32	−10	−2	4.48	0.034	12.78 ± 3.68	12.03 ± 3.61	1.90 ± 0.11	1.73 ± 0.12
Midbrain/Pons		0	−36	−10	4.51	0.034	9.49 ± 2.75	8.45 ± 2.88	1.41 ± 0.07	1.20 ± 0.19
Cerebellum lobules IV-VIa	Right	14	−48	−20	4.72	0.001	11.02 ± 3.29	10.01 ± 0.63	1.63 ± 0.11	1.43 ± 0.14
	Left	−2	−60	−16	4.61	0.005	10.82 ± 3.13	9.65 ± 0.62	1.61 ± 0.11	1.38 ± 0.18

^aMontreal Neurological Institute (MNI) standard space. Cerebellar localization according to the atlas of Schmahmann (Schmahmann et al., 2000)

^bFWE-corrected (see text).

^cMean values (±SD) measured in spherical (radius = 4mm) volumes-of-interest (VOIs) centered at the peak voxel of each of the listed regions.

^dmg/min/l00g

^eCerebral metabolic rate/GMR