Table 2.

Effects of Traumatic Brain Injury (TBI) and Dietary Choline Supplementation on the Density of Non-α7 nAChRs as Measured by [¹²⁵I]-Epibatidine-Autoradiography

	Standard choline diet		Choline supplemented diet
Brain region	Sham	CCI	Sham	CCI
Auditory cortex layer 2	1.01 ± 0.12	0.85 ± 0.15	0.99 ± 0.06	0.96 ± 0.1
Auditory cortex layers 3–6	0.61 ± 0.05	0.53 ± 0.04	0.63 ± 0.05	0.62 ± 0.0
Striatum	1.07 ± 0.17	1.22 ± 0.1	1.14 ± 0.16	1.21 ± 0.1
Dentate gyrus (medial blade)	0.71 ± 0.13	0.62 ± 0.1	0.72 ± 0.12	0.78 ± 0.1
Dentate gyrus (lateral blade)	0.49 ± 0.06	0.42 ± 0.04	0.50 ± 0.07	0.53 ± 0.0
Superior colliculus	2.79 ± 0.5	3.00 ± 0.6	2.81 ± 0.46	2.72 ± 0.4
VPL/VPM	1.58 ± 0.29	1.58 ± 0.15	1.59 ± 0.3	1.71 ± 0.2
Medial habenula	4.83 ± 0.69	5.59 ± 0.57*	4.51 ± 0.49	5.26 ± 0.6*,†
Subiculum	1.19 ± 0.20	1.22 ± 0.22	1.10 ± 0.13	1.14 ± 0.2
Medial geniculate nucleus	1.68 ± 0.20	1.61 ± 0.33	1.40 ± 0.26	1.57 ± 0.4
Fasciculus retroflexus	2.84 ± 0.37	3.06 ± 0.35	3.01 ± 0.49	2.88 ± 0.2

In animals maintained on the standard choline diet, TBI increased binding in only the medial habenula. Choline administration did not generally affect non-α7 nAChR density.

^*p < 0.05, significantly different from sham-operated animals maintained on the standard choline diet.

^†p < 0.05, significantly different from sham-operated animals maintained on the choline-supplemented diet (SNK).